67
Participants
Start Date
September 10, 2024
Primary Completion Date
December 30, 2025
Study Completion Date
June 30, 2027
Memantine Oral Tablet
"Oral administration of Memantine Tablets (10mg/tablet):~Week 1: 5mg in the morning. Week 2: 5mg twice daily. Week 3: 10mg in the morning, 5mg in the evening. Weeks 4-24: 10mg twice daily."
Pioglitazone 15mg
"Simultaneous oral administration of Pioglitazone Tablets (15mg/tablet):~Weeks 1-24: 30mg once daily."
Hippocampal avoidance whole-brain radiotherapy (HA-WBRT)
Based on the RTOG 0933 protocol, hippocampal and perihippocampal regions are delineated, and hippocampal dose constraints are applied. The radiation dose to the perihippocampal region is determined based on the size, number, and volume of brain metastases (whole-brain radiation therapy: DT 30Gy/10F, weeks 1-2; with a simultaneous boost to the pathological local area if necessary, 10-20Gy).
Guangdong Provincial People's Hospital
OTHER
Fujian Medical University Union Hospital
OTHER
Southern Medical University, China
OTHER
The Affiliated Panyu Center Hospital of Guangzhou Medical University
UNKNOWN
The Central Hospital of Shaoyang City
UNKNOWN
Affiliated Cancer Hospital & Institute of Guangzhou Medical University
OTHER