6,000
Participants
Start Date
October 21, 2024
Primary Completion Date
October 4, 2025
Study Completion Date
October 5, 2025
Clinical Evaluation at Day 4
Participants will undergo an abbreviated physical exam, assessment of concomitant medications, and reassessment for signs/symptoms of TB
Laboratory Evaluation at Day 4
Peripheral blood samples, including serum, PBMC, and whole blood, are collected from participants. A tongue swab is also collected from each participant.
Clinical Evaluation at week 26
Participants will undergo another complete physical exam and have their medical (including TB) history, potential TB signs/symptoms, and concomitant medications reassessed. Chest radiography will be obtained for all participants. An assessment of TB outcomes will also be performed.
Laboratory Evaluation at week 26
Peripheral blood samples, including serum, PBMC, and whole blood, will be collected. Participants not previously identified as living with HIV will undergo HIV diagnostic testing, while participants living with HIV will have their HIV viral load and CD4+ T-cell count measured.
RECRUITING
Gaborone CRS, Gaborone
RECRUITING
Eswatini Prevention Center CRS, Mbabane
RECRUITING
Moi University Clinical Research Centre, Eldoret
RECRUITING
Kisumu Crs, Kisumu
RECRUITING
Kombewa Clinical Research Center, Kisumu
RECRUITING
Blantyre CRS, Blantyre
RECRUITING
Malawi CRS, Lilongwe
RECRUITING
Synergy Biomed Research Institute, East London
RECRUITING
Nelson Mandela Academic Research Unit CRS, Mthatha
RECRUITING
PHOENIX Pharma (Pty) Ltd, Port Elizabeth
RECRUITING
Josha Resarch CRS, Bloemfontein
RECRUITING
MeCRU CRS, Ga-Rankuwa
RECRUITING
Clinical HIV Research Unit (CHRU)/ Helen Joseph CRS, Johannesburg
RECRUITING
Newtown Clinical Research, Johannesburg
RECRUITING
Soweto - Bara CRS, Johannesburg
RECRUITING
Wits RHI Ward 21 CRS, Johannesburg
RECRUITING
Tembisa Clinic 4 CoVPN CRS, Tembisa
RECRUITING
CAPRISA eThekwini CRS, Durban
RECRUITING
Tongaat CRS, Durban
RECRUITING
Vulindlela CRS, Durban
RECRUITING
Isipingo CRS, Isipingo
RECRUITING
Qhakaza Mbokodo Research Clinic CRS, Ladysmith
RECRUITING
Aurum Institute Klerksdorp CRS, Klerksdorp
RECRUITING
Rustenburg CRS, Rustenburg
RECRUITING
Emavundleni CRS, Cape Town
RECRUITING
FAM-CRU (Family Clinical Research Unit), Cape Town
RECRUITING
Groote Schuur HIV CRS, Cape Town
RECRUITING
Masiphumelele Clinical Research Site (MASI) CRS, Cape Town
RECRUITING
TASK Central, Cape Town
RECRUITING
Univeristy of Cape Town Lung CRS Institute, Cape Town
RECRUITING
TASK Eden, George
RECRUITING
Kliptown Soweto CRS, Johannesburg
RECRUITING
PHRU Matlosana CRS, Klerksdorp
RECRUITING
UVRI-IAVI HIV Vaccine Program LTD. CRS, Entebbe
RECRUITING
Baylor-Uganda CRS, Kampala
RECRUITING
Joint Clinical Research Centre, Kampala
RECRUITING
MU-JHU Research Collaboration CRS, Kampala
RECRUITING
Cfhrz Crs, Lusaka
RECRUITING
Matero Reference Clinic CRS, Lusaka
RECRUITING
UNC Global Projects / Kamwala District Health Centre, Lusaka
RECRUITING
Zambia Emory HIV Research Project - Ndola CoVPN CRS, Ndola
National Institute of Allergy and Infectious Diseases (NIAID)
NIH
Medical Research Council, South Africa
OTHER
COVID-19 Prevention Network
NETWORK