NCT06584357 - Development of a Database to Investigate Digital and Blood-Based Biomarkers and Their Relationship to Tau and Amyloid PET Imaging in Older Participants Who Are Cognitively Normal (CN), Have Mild Cognitive Impairment (MCI), or Have Mild-to-Moderate AD Dementia | Biotech Hunter

Enrollment

1,200

Participants

Timeline

Start Date

September 26, 2024

Primary Completion Date

July 31, 2028

Study Completion Date

July 31, 2028

Conditions

Mild Cognitive ImpairmentAlzheimer's DiseaseAlzheimer's Disease, Early OnsetMemory LossMemory DisordersMemory Impairment

Interventions

OTHER

Biomarker Data Collection

During this study, a sample of your blood will be collected and you will have a PET scan taken of your brain. Blood sample results will be compared to PET scan pictures to understand how well the markers in the blood predict whether there is amyloid in the brain. Blood samples will also be collected that contain your genes. These genetic samples will also be compared to PET scans to help researchers understand how different people react to medicines and to understand the genetic causes of AD. Some of the samples will be stored for future analysis.

RADIATION

MK6240

Each participant will be assessed using either one of two radioactive tau PET tracers: Flortaucipir or MK6240. Flortaucipir is FDA approved while MK6240 is not and is being used in this study as an investigational radioactive drug.

Trial Locations (23)

12208

COMPLETED

ADRC of Albany, Albany

19462

RECRUITING

Flourish Research - Philadelphia, Philadelphia

32127

RECRUITING

Progressive Medical Research, Port Orange

32751

RECRUITING

K2 Medical Research, Maitland

32789

RECRUITING

Conquest Research, Winter Park

32803

RECRUITING

Charter Research, Orlando

32940

RECRUITING

Clincloud, Melbourne

33133

RECRUITING

Visionary Investigators Network, Miami

33180

RECRUITING

Visionary Investigators Network, Aventura

33445

RECRUITING

Brain Matters Research, Delray Beach

33462

RECRUITING

JEM Research Institute, Atlantis

33609

RECRUITING

Axiom Brain Health, Tampa

33912

RECRUITING

Neuropsychiatric Research Center of SW Florida, Fort Myers

34239

RECRUITING

Intercoastal Medical Group, Inc., Sarasota

34711

RECRUITING

K2 - Winter Garden, Clermont

44720

RECRUITING

Neuro-Behavioral Clinical Research Inc., North Canton

48334

RECRUITING

Quest Research Institute, Farmington Hills

60640

RECRUITING

Flourish Research - Chicago, Chicago

77030

RECRUITING

Re:Cognition Health, Houston

77702

RECRUITING

Gadolin Research LLC, Beaumont

M3B 2S7

RECRUITING

Toronto Memory Program, Toronto

ML1 4UF

RECRUITING

NeuroClin Glasgow, Motherwell

W1G 8TA

RECRUITING

Re:Cognition Health, London