Comparison of Remifentanil with a Combination of Remimazolam and Dexmedetomidine for Awake Tracheal Intubation

NARecruitingINTERVENTIONAL
Enrollment

60

Participants

Timeline

Start Date

September 19, 2024

Primary Completion Date

September 10, 2025

Study Completion Date

October 20, 2025

Conditions
Difficult or Failed IntubationSedative Adverse Reaction
Interventions
DRUG

remimazolam combined with remifentanil

Patients in this group will receive a bolus of remimazolam 5 mg intravenously, and then a dose of 0.1 μg/kg/min remifentanil and 0.5 mg/kg/h remimazolam via separate syringe pumps.

DRUG

dexmedetomidine combined with remifentanil

Patients in this group will receive a loading dose of dexmedetomidine 1 μg/kg over 10 minutes intravenously, and then a dose of 0.1 μg/kg/min remifentanil and 0.5 μg/kg/h dexmedetomidine via separate syringe pumps.

Trial Locations (1)

210000

RECRUITING

Nanjing First Hospital, Nanjing

All Listed Sponsors
lead

Nanjing First Hospital, Nanjing Medical University

OTHER