A Randomized, Phase 2/3 Study to Investigate the Efficacy and Safety of RP2 in Combination With Nivolumab in Immune Checkpoint Inhibitor-Naïve Adult Patients With Metastatic Uveal Melanoma

PHASE2/PHASE3RecruitingINTERVENTIONAL
Enrollment

280

Participants

Timeline

Start Date

December 17, 2024

Primary Completion Date

January 31, 2030

Study Completion Date

October 31, 2031

Conditions
Metastatic Uveal Melanoma
Interventions
BIOLOGICAL

RP2

Genetically modified herpes simplex type 1 virus for tumor lysis and immune stimulation.

BIOLOGICAL

Ipilimumab

Ipilimumab: human cytotoxic T-lymphocyte antigen 4 (CTLA-4)-blocking antibody

BIOLOGICAL

Nivolumab

Nivolumab: Anti-PD-1 Monoclonal antibody

Trial Locations (24)

10065

RECRUITING

Memorial Sloan Kettering Cancer Center, New York

15232

RECRUITING

UPMC Hillman Cancer Center, Pittsburgh

19107

RECRUITING

Thomas Jefferson University, Philadelphia

20007

RECRUITING

Georgetown University Medical Center, Washington D.C.

27710

RECRUITING

Duke University Medical Center, Durham

30322

RECRUITING

Emory Winship Cancer Institute, Atlanta

33136

RECRUITING

Sylvester Comprehensive Cancer Center, Miami

37203

RECRUITING

Sarah Cannon Research Institute, Nashville

37232

RECRUITING

Vanderbilt Ingram Cancer Center (Henry-Joyce Cancer Clinic), Nashville

38138

RECRUITING

The West Clinic, PLLC dba West Cancer Center, Germantown

43210

RECRUITING

The Ohio State University, Columbus

52242

RECRUITING

University of Iowa, Iowa City

53792

RECRUITING

University Of Wisconsin Carbone Cancer Center - University Hospital, Madison

60611

RECRUITING

Northwestern Memorial Hospital, Chicago

60637

RECRUITING

University of Chicago Medical Center, Chicago

75390

RECRUITING

UT Southwestern Medical Center, Dallas

77030

RECRUITING

The University Of Texas Md Anderson Cancer Center, Houston

80113

RECRUITING

The Melanoma & Skin Cancer Institute, Englewood

85258

RECRUITING

HonorHealth Research Insisute, Scottsdale

90025

RECRUITING

The Angeles Clinic and Research Institute, Los Angeles

90095

RECRUITING

University of California Los Angeles, Los Angeles

92037

RECRUITING

UC San Diego Moores Cancer Center, La Jolla

94304

RECRUITING

Stanford Cancer Institute, Palo Alto

02114

RECRUITING

Massachusetts General Hospital, Boston

All Listed Sponsors
lead

Replimune Inc.

INDUSTRY