Surgery and Reducing Ionizing Radiation of the Unknown Primary

PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

90

Participants

Timeline

Start Date

January 1, 2025

Primary Completion Date

December 31, 2026

Study Completion Date

May 30, 2027

Conditions
Head and Neck Squamous Cell CarcinomaHPV Positive Oropharyngeal Squamous Cell Carcinoma
Interventions
RADIATION

Intensity Modulated Radiotherapy (IMRT) to Mucosa at Risk

Patients in Arm 1, after the surgical procedure, will receive radiotherapy to the at-risk mucosa.

PROCEDURE

Surgical Intervention

These patients will undergo Neck dissection, TORS tonsillectomy (unilateral vs bilateral tonsillectomy at the discretion of the treating physician) + ipsilateral tongue base mucosectomy.

RADIATION

Intensity Modulated Radiotherapy (IMRT) to Ipsilateral Neck

For Arm1, after the surgical procedure, the patients will receive radiotherapy to the ipsilateral neck. For Arm2, the patients will only receive IMRT to neck, if multiple ipsilateral nodes or single ipsilateral node \>3 cm is observed

Trial Locations (3)

5000

Royal Adelaide Hospital, Adelaide

5042

Flinders Medical Centre, Adelaide

N6A 5W9

London Health Sciences Centre, London

All Listed Sponsors
collaborator

Dr. Jake Jervis-Bardy

UNKNOWN

collaborator

Dr. David Palma

UNKNOWN

collaborator

Dr. Adam Mutsaers

UNKNOWN

lead

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

OTHER