A Study of Different Sequences of Cilta-cel, Talquetamab in Combination With Daratumumab and Teclistamab in Combination With Daratumumab Following Induction With Daratumumab, Bortezomib, Lenalidomide and Dexamethasone in Participants With Standard-risk Newly Diagnosed Multiple Myeloma

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

43

Participants

Timeline

Start Date

August 20, 2024

Primary Completion Date

July 31, 2030

Study Completion Date

September 2, 2030

Conditions
Multiple Myeloma
Interventions
DRUG

Cilta-cel

Cilta-cel infusion will be administered intravenously.

DRUG

Talquetamab

Talquetamab will be administered subcutaneously.

DRUG

Daratumumab

Daratumumab will be administered subcutaneously as a part of DVRd induction and Tal-D or Tec-D consolidation.

DRUG

Teclistamab

Teclistamab will be administered subcutaneously.

DRUG

Bortezomib

Bortezomib will be administered subcutaneously as a part of induction.

DRUG

Lenalidomide

Lenalidomide will be administered orally as a part of induction.

DRUG

Dexamethasone

Dexamethasone will be administered orally as a part of induction.

DRUG

Cyclophosphamide

Cyclophosphamide will be administered intravenously as a part of conditioning regimen.

DRUG

Fludarabine

Fludarabine will be administered intravenously as a part of conditioning regimen.

Trial Locations (16)

3000

Peter MacCallum Cancer Centre, Melbourne

3004

The Alfred Hospital, Melbourne

10065

Memorial Sloan Kettering Cancer Center, New York

28041

Hosp. Univ. 12 de Octubre, Madrid

28204

Levine Cancer Institute, Charlotte

37007

Hosp Clinico Univ de Salamanca, Salamanca

39008

Hosp. Univ. Marques de Valdecilla, Santander

52242

University of Iowa Hospital and Clinics, Iowa City

69120

Universitaetsklinikum Heidelberg, Heidelberg

72076

Universitaetsklinikum Tuebingen, Tübingen

91010

City of Hope, Duarte

94143

University of California San Francisco, San Francisco

97080

Universitatsklinikum Wurzburg, Würzburg

41253 190

Instituto D Or de Pesquisa e Ensino, Salvador

01509 900

Fundacao Antonio Prudente A C Camargo Cancer Center, São Paulo

05652 900

Sociedade Beneficente Israelita Brasileira Hospital Albert Einstein, São Paulo

All Listed Sponsors
lead

Janssen Research & Development, LLC

INDUSTRY