Better Options for Chronic Cancer Pain

PHASE4Not yet recruitingINTERVENTIONAL
Enrollment

294

Participants

Timeline

Start Date

October 1, 2025

Primary Completion Date

April 1, 2029

Study Completion Date

December 31, 2029

Conditions
Chronic PainCancer SurvivorOpioid Dependence
Interventions
BEHAVIORAL

Multimodal pain care

Behavioral therapy (as below), physical therapy, assistive devices (e.g. TENS, bracing), referrals to VA specialists (e.g. interventional pain), and complementary and integrative therapies (e.g. acupuncture or massage

DRUG

Medication optimization

Medications will be optimized following an algorithm the investigators created based upon NCCN's Survivorship Guidelines and AHRQ's comprehensive review of non-opioid treatments for chronic pain.

DEVICE

Buprenorphine rotation

Subjects randomized to this arm at 6 months will be offered the chance to rotate from their full mu agonist opioid to buprenorphine using a standardized protocol

OTHER

Opioid tapering

Subjects randomized to tapering will receive recommendations based upon the VA PBM's opioid tapering reference guide

Trial Locations (2)

46202-2884

Richard L. Roudebush VA Medical Center, Indianapolis, IN, Indianapolis

48105-2303

VA Ann Arbor Healthcare System, Ann Arbor, MI, Ann Arbor

All Listed Sponsors
lead

VA Office of Research and Development

FED