294
Participants
Start Date
October 1, 2025
Primary Completion Date
April 1, 2029
Study Completion Date
December 31, 2029
Multimodal pain care
Behavioral therapy (as below), physical therapy, assistive devices (e.g. TENS, bracing), referrals to VA specialists (e.g. interventional pain), and complementary and integrative therapies (e.g. acupuncture or massage
Medication optimization
Medications will be optimized following an algorithm the investigators created based upon NCCN's Survivorship Guidelines and AHRQ's comprehensive review of non-opioid treatments for chronic pain.
Buprenorphine rotation
Subjects randomized to this arm at 6 months will be offered the chance to rotate from their full mu agonist opioid to buprenorphine using a standardized protocol
Opioid tapering
Subjects randomized to tapering will receive recommendations based upon the VA PBM's opioid tapering reference guide
Richard L. Roudebush VA Medical Center, Indianapolis, IN, Indianapolis
VA Ann Arbor Healthcare System, Ann Arbor, MI, Ann Arbor
VA Office of Research and Development
FED