Atomoxetine and Executive Function in PTSD

PHASE4Not yet recruitingINTERVENTIONAL
Enrollment

160

Participants

Timeline

Start Date

November 17, 2025

Primary Completion Date

June 29, 2029

Study Completion Date

September 28, 2029

Conditions
Posttraumatic Stress Disorder With Attention Defic
Interventions
DRUG

Atomoxetine

Atomoxetine is a selective norepinephrine reuptake inhibitor medication used to treat attention deficit hyperactivity disorder (ADHD), and executive dysfunction. Dispensing of blinded medication (40mg to 80mg ATX or placebo) will begin at randomization and will be dispensed at weeks 2, 4, 8, and 12. The initial dose of ATX is 40mg or placebo and will be given for one week, the dose will be titrated to 80mg if tolerated in the second week through week 12.

DRUG

Placebo

placebo pill appears like real atomoxetine pill but has no therapeutic ingredient and benefit. The same schedule to distribution as Atomoxetine arm.

Trial Locations (1)

29401-5703

Ralph H. Johnson VA Medical Center, Charleston, SC, Charleston

All Listed Sponsors
collaborator

Medical University of South Carolina

OTHER

lead

VA Office of Research and Development

FED