Study on the Relative Dose Intensity of PARP Inhibitors in Real-life on a Population of Patients Over 70 Years With Advanced Ovarian Cancer

Not yet recruitingOBSERVATIONAL
Enrollment

50

Participants

Timeline

Start Date

November 1, 2024

Primary Completion Date

May 1, 2026

Study Completion Date

May 1, 2026

Conditions
Ovarian Cancer
Interventions
OTHER

QoL surveys

2 quality of life surveys (OV28 and ELD14) will be completed by patients every 3 months during a 12-month period

OTHER

Geriatric assessment (G-CODE)

A geriatric assessment (G-CODE) will be performed by the research staff every 3 months during a 12-month period

BIOLOGICAL

Blood sampling

A supplementary volume of blood will be collected from a routine blood sample (8 mL) at 3 different time points : one at inclusion, one 6 and 12 months after the beginning of PARP inhibitors treatment. Genetic lab test will be performed to assess whether there is a specific genetic signature for PARP inhibitors toxicity.

Trial Locations (9)

21079

Centre Georges François Leclerc, Dijon

41260

Polyclinique de Blois, La Chaussée-Saint-Victor

42271

Institut de Cancérologie et d'Hématologie Universitaire de Saint Etienne, Saint-Priest-en-Jarez

60100

Groupe Hospitalier Public Sud de l'Oise, Creil

63011

Centre de lutte contre le cancer Jean Perrin, Clermont-Ferrand

69004

Service Hôpital de jour / Oncologie Médicale, Hôpital de la Croix Rousse, Lyon

69317

Service de Gériatrie, Hôpital Dr Frédéric Dugoujon, Lyon

69495

Service Oncologie Médicale, Hôpital Lyon Sud, Pierre-Bénite

80054

Centre Hospitalier Universitaire d'Amiens Picardie Site Sud, Amiens

All Listed Sponsors
lead

Hospices Civils de Lyon

OTHER

NCT06572735 - Study on the Relative Dose Intensity of PARP Inhibitors in Real-life on a Population of Patients Over 70 Years With Advanced Ovarian Cancer | Biotech Hunter | Biotech Hunter