De-escalation Radiation Strategy After NAC in Combination With ICI in LAHNSCC

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

20

Participants

Timeline

Start Date

October 17, 2023

Primary Completion Date

September 30, 2026

Study Completion Date

April 30, 2027

Conditions
Locally Advanced Head and Neck Squamous Cell Carcinoma
Interventions
DRUG

immunotherapy:pembrolizumab;chemo:albumin-bound paclitaxel and cisplatin

The immunotherapy drug was pembrolizumab at a dose of 200 mg, administered on the first day of each cycle every 3 weeks. The induction chemotherapy regimen included albumin-bound paclitaxel at 260 mg/m2 and cisplatin at 75 mg/m2, given every 3 weeks, either concurrently with immunotherapy or on the second day.

Trial Locations (1)

200025

RECRUITING

Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai

All Listed Sponsors
lead

Ruijin Hospital

OTHER