Safety and Efficacy of Intravenous Thrombolysis in Patients With Ischemic Stroke and Direct Oral Anticoagulants Intake

PHASE4RecruitingINTERVENTIONAL
Enrollment

906

Participants

Timeline

Start Date

March 14, 2025

Primary Completion Date

January 31, 2029

Study Completion Date

April 30, 2029

Conditions
Ischemic Stroke
Interventions
DRUG

Tenecteplase or Alteplase

Patients randomized to intravenous thrombolysis (IVT) treatment will receive intravenous Tenecteplase or Alteplase.

Trial Locations (14)

1105

NOT_YET_RECRUITING

Academic Medical Center Amsterdam, Department of Neurology, Amsterdam

3000

NOT_YET_RECRUITING

UZ Leuven, Leuven

3010

RECRUITING

Inselspital Bern, Bern

4031

NOT_YET_RECRUITING

University Hospital Basel, Basel

8011

NOT_YET_RECRUITING

Canterbury District Health Board, Christchurch

12462

NOT_YET_RECRUITING

"Attikon University Hospital", Athens

69120

NOT_YET_RECRUITING

Heidelberg University Hospital, Heidelberg

75014

NOT_YET_RECRUITING

GHU Paris Psychiatrie et Neurosciences, Sainte Anne, Paris

L8L 2X2

NOT_YET_RECRUITING

Hamilton Health Sciences, Hamilton

565-8565

NOT_YET_RECRUITING

National Cerebral and Cardiovascular Center Osaka, Osaka

Unknown

NOT_YET_RECRUITING

Akershus Hospital, Oslo

RECRUITING

Kantonsspital St. Gallen, Sankt Gallen

1150-199

NOT_YET_RECRUITING

Lisbon Central University Hospital Centre, Lisbon

08035

NOT_YET_RECRUITING

Vall d'Hebron Stroke Center, Barcelona

All Listed Sponsors
lead

Insel Gruppe AG, University Hospital Bern

OTHER