The Effect of Dexmedetomidine on the Renal Functions in Septic Critically Ill Patients

Dexmedetomidine will be administered with an initial dose of 0.2 μg/kg/hour, infusion rate is to be titrated based on response for at least 24 hours.

Propofol will be administered as the comparator sedative with the standard treatment of sepsis and septic shock.