NCT06566794 - KF2022#4-trial: Effects of a Beta Blocker and NSAID on CYP Mediated Drug Metabolism | Biotech Hunter

Enrollment

Participants

Timeline

Start Date

August 20, 2024

Primary Completion Date

December 31, 2024

Study Completion Date

December 31, 2025

Conditions

Drug Interaction

Interventions

DRUG

Caffeine Tablet

0,5 x 100 mg tablet (50 mg caffeine).

DRUG

Bupropion Hydrochloride Capsels

1 x 20 mg tablet.

DRUG

Repaglinide Capsels

1 x 0,05 mg tablet.

DRUG

Flurbiprofen Capsels

1 x 10 mg tablet.

DRUG

Omeprazole 10 MG

1 x 10 mg tablet.

DRUG

Dextromethorphan Oral Solution

5,0 ml of 2 mg/ml oral solution (10 mg dextromethorphan).

DRUG

Midazolam oral solution

0,5 ml of 2 mg/ml oral solution (1,0 mg midazolam).

DRUG

Simvastatin tablets

1 x 10 mg tablet.

DRUG

Placebo

2 x placebo tablets in the Placebo Phase/Arm

DRUG

Carvedilol

2 x 25 mg tablets

DRUG

Diclofenac

1 x 50 mg tablet (three times daily for three days)

Trial Locations (1)

Unknown

Department of Clinical Pharmacology, Helsinki

All Listed Sponsors

collaborator

University of Helsinki

OTHER

lead

Helsinki University Central Hospital

OTHER