A Study of AZD0486 Monotherapy or in Combination With Other Anti-Cancer Agents for Mature B-Cell Malignancies

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

276

Participants

Timeline

Start Date

January 30, 2025

Primary Completion Date

April 25, 2031

Study Completion Date

April 25, 2031

Conditions
Chronic Lymphocytic LeukaemiaSmall Lymphocytic LymphomaMantle-cell LymphomaLarge B-cell LymphomaB-cell Non-Hodgkin Lymphoma
Interventions
DRUG

AZD0486

AZD0486 will be administered as either SC injection or IV infusion.

DRUG

Prednisone (or equivalent)

Prednisone (or equivalent) will be administered either oral or IV infusion as per standard of care.

DRUG

Rituximab

Rituximab will be administered as IV infusion as per standard of care.

DRUG

Cyclophosphamide

Cyclophosphamide will be administered as IV infusion as per standard of care.

DRUG

Vincristine

Vincristine will be administered as IV infusion as per standard of care.

DRUG

Doxorubicin

Doxorubicin will be administered as IV infusion as per standard of care.

DRUG

Acalabrutinib

Acalabrutinib will be administered orally

Trial Locations (57)

100

RECRUITING

Research Site, Taipei

500

RECRUITING

Research Site, Changhua

710

RECRUITING

Research Site, Tainan City

2100

RECRUITING

Research Site, Copenhagen

3004

RECRUITING

Research Site, Melbourne

3084

RECRUITING

Research Site, Heidelberg

5000

NOT_YET_RECRUITING

Research Site, Odense C

6009

RECRUITING

Research Site, Nedlands

7120

RECRUITING

Research Site, Palma de Mallorca

8036

RECRUITING

Research Site, Barcelona

8200

RECRUITING

Research Site, Aarhus N

9000

RECRUITING

Research Site, Aalborg

10029

RECRUITING

Research Site, New York

12808

RECRUITING

Research Site, Prague

12820

RECRUITING

Research Site, Praha 2 - Nové Město

15232

NOT_YET_RECRUITING

Research Site, Pittsburgh

15706

RECRUITING

Research Site, Santiago de Compostela

19104

RECRUITING

Research Site, Philadelphia

24105

NOT_YET_RECRUITING

Research Site, Kiel

28034

RECRUITING

Research Site, Madrid

28040

RECRUITING

Research Site, Madrid

28204

RECRUITING

Research Site, Charlotte

34295

RECRUITING

Research Site, Montpellier

43210

NOT_YET_RECRUITING

Research Site, Columbus

46026

RECRUITING

Research Site, Valencia

48108

RECRUITING

Research Site, Busan

50937

NOT_YET_RECRUITING

Research Site, Cologne

63000

NOT_YET_RECRUITING

Research Site, Clermont-Ferrand

75010

RECRUITING

Research Site, Paris

77030

NOT_YET_RECRUITING

Research Site, Houston

81377

RECRUITING

Research Site, München

83301

RECRUITING

Research Site, Kaohsiung City

92210

RECRUITING

Research Site, Saint-Cloud

94805

RECRUITING

Research Site, Villejuif

97080

RECRUITING

Research Site, Würzburg

97239

NOT_YET_RECRUITING

Research Site, Portland

100044

RECRUITING

Research Site, Beijing

250013

WITHDRAWN

Research Site, Jinan

300060

RECRUITING

Research Site, Tianjin

450008

RECRUITING

Research Site, Zhengzhou

510060

RECRUITING

Research Site, Guangzhou

02215

RECRUITING

Research Site, Boston

07601

NOT_YET_RECRUITING

Research Site, Hackensack

08901

RECRUITING

Research Site, New Brunswick

02903

RECRUITING

Research Site, Providence

708 52

RECRUITING

Research Site, Ostrava - Poruba

135-8550

RECRUITING

Research Site, Kōtoku

791-0280

RECRUITING

Research Site, Matsuyama

464-8681

RECRUITING

Research Site, Nagoya

02841

RECRUITING

Research Site, Seoul

03080

RECRUITING

Research Site, Seoul

05505

RECRUITING

Research Site, Seoul

06351

RECRUITING

Research Site, Seoul

06591

RECRUITING

Research Site, Seoul

PL6 5FP

RECRUITING

Research Site, Derriford

SE5 9RS

RECRUITING

Research Site, London

0X3 7LJ

RECRUITING

Research Site, Oxford

Sponsors

Lead Sponsor

All Listed Sponsors
lead

AstraZeneca

INDUSTRY