96
Participants
Start Date
September 25, 2024
Primary Completion Date
November 15, 2029
Study Completion Date
November 15, 2039
Brentuximab Vedotin for Injection
1.8mg/kg/dose (MAX 180 mg)
response-adapted radiation
For patients who did not achieve complete metabolic response at early response assessment based on PET/CT result.
Doxorubicin
25mg/m2/dose,
Etoposide
125 mg/m2/dose
Prednisone
20 mg/m2, BID, orally
Cyclophosphamide
600 mg/m2/dose
Dacarbazine
250 mg/m2/dose; For patients in intermediate/high risk group who did not achieve complete metabolic response at early assessment based on PET/CT results.
Tislelizumab Injection
3mg/kg/dose; For patients in intermediate/high risk group who did not achieve complete metabolic response at late assessment based on PET/CT results.
Bedamustine
180mg/m2/dose; For patients in intermediate/high risk group who did not achieve complete metabolic response at late assessment based on PET/CT results.
RECRUITING
Shanghai Children's Medical Center, Shanghai
Shanghai Children's Medical Center
OTHER
Najing Children's Hospital
UNKNOWN
West China Second University Hospital
OTHER
Qilu Hospital of Shandong University
OTHER
Tianjin Medical University Cancer Institute and Hospital
OTHER
Tongji Hospital
OTHER
Xiangya Hospital of Central South University
OTHER
The First Affiliated Hospital of Zhengzhou University
OTHER
Second Affiliated Hospital of Anhui Medical University
UNKNOWN
Children's Hospital of Hebei Province
OTHER
Children's Hospital of Henan Province
UNKNOWN
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
OTHER
Children's Cancer Group, China
NETWORK