Brentuximab Vedotin for Newly Diagnosed CHL in Chinese CAYA Based on PET/CT Assessment

PHASE2/PHASE3RecruitingINTERVENTIONAL
Enrollment

96

Participants

Timeline

Start Date

September 25, 2024

Primary Completion Date

November 15, 2029

Study Completion Date

November 15, 2039

Conditions
Classical Hodgkin LymphomaChildAdolescentYoung AdultMetabolic ResponseSurvivalTreatmentBrentuximab VedotinPET Scan
Interventions
DRUG

Brentuximab Vedotin for Injection

1.8mg/kg/dose (MAX 180 mg)

RADIATION

response-adapted radiation

For patients who did not achieve complete metabolic response at early response assessment based on PET/CT result.

DRUG

Doxorubicin

25mg/m2/dose,

DRUG

Etoposide

125 mg/m2/dose

DRUG

Prednisone

20 mg/m2, BID, orally

DRUG

Cyclophosphamide

600 mg/m2/dose

DRUG

Dacarbazine

250 mg/m2/dose; For patients in intermediate/high risk group who did not achieve complete metabolic response at early assessment based on PET/CT results.

DRUG

Tislelizumab Injection

3mg/kg/dose; For patients in intermediate/high risk group who did not achieve complete metabolic response at late assessment based on PET/CT results.

DRUG

Bedamustine

180mg/m2/dose; For patients in intermediate/high risk group who did not achieve complete metabolic response at late assessment based on PET/CT results.

Trial Locations (1)

Unknown

RECRUITING

Shanghai Children's Medical Center, Shanghai

All Listed Sponsors
collaborator

Shanghai Children's Medical Center

OTHER

collaborator

Najing Children's Hospital

UNKNOWN

collaborator

West China Second University Hospital

OTHER

collaborator

Qilu Hospital of Shandong University

OTHER

collaborator

Tianjin Medical University Cancer Institute and Hospital

OTHER

collaborator

Tongji Hospital

OTHER

collaborator

Xiangya Hospital of Central South University

OTHER

collaborator

The First Affiliated Hospital of Zhengzhou University

OTHER

collaborator

Second Affiliated Hospital of Anhui Medical University

UNKNOWN

collaborator

Children's Hospital of Hebei Province

OTHER

collaborator

Children's Hospital of Henan Province

UNKNOWN

collaborator

Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University

OTHER

lead

Children's Cancer Group, China

NETWORK