CT011 Autologous CAR-T Cells in Patients With Hepatocellular Carcinoma at Risk of Recurrence After Surgical Resection

PHASE1RecruitingINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

October 8, 2023

Primary Completion Date

December 31, 2026

Study Completion Date

June 30, 2027

Conditions
HCC
Interventions
BIOLOGICAL

CT011 CAR-GPC3 T Cells Injection

The dose selection for this trial was mainly based on the preliminary safety and efficacy results of CT011-HCC-01 trial in subjects with advanced HCC, in which 3 and 5 subjects in the 2.5 × 108 cell and 5.0 × 108 cell dose groups, respectively, completed a single infusion of CT011. The results showed that the two dose groups of CT011 were generally well tolerated in HCC subjects who failed to standard treatment, with controllable safety, and showed preliminary anti-tumor efficacy.

Trial Locations (15)

Unknown

RECRUITING

Cancer Hospital Chinese Academy of Medical Sciences, Beijing

RECRUITING

Hunan Provincial People's Hospital, Changsha

RECRUITING

Sichuan Cancer Hospital, Chengdu

RECRUITING

West China Hospital of Sichuan University, Chengdu

RECRUITING

Chongqing university ca cer hospital, Chongqing

RECRUITING

Mengchao hepatobiliary hospital of fujian medical university, Fuzhou

RECRUITING

Sun Yat-sen University Cancer Center, Guanzhou

RECRUITING

Sir Run Run Shaw Hospital Zhejiang University School of Medicine, Hangzhou

RECRUITING

The second affiliated hospital zhejiang university school of medicine, Hangzhou

RECRUITING

Zhongshan Hospital Fudan University, Shanghai

RECRUITING

Liaoning Cancer Hospital, Shenyang

RECRUITING

The first hospital of china medical university, Shenyang

RECRUITING

Tianjin medical university cancer hospital, Tianjin

RECRUITING

Tongji Hospital affiliated to Tongji Medical College of Huazhong University of Science & Technology, Wuhan

RECRUITING

The First Affiliated Hospital of Zhengzhou University, Zhengzhou

Sponsors
All Listed Sponsors
collaborator

Shanghai Zhongshan Hospital

OTHER

lead

CARsgen Therapeutics Co., Ltd.

INDUSTRY