Cervical Boost by Ablative Stereotactic Radiotherapy (SABR) vs Brachytherapy in Patients With Cervical Carcinoma

NARecruitingINTERVENTIONAL
Enrollment

84

Participants

Timeline

Start Date

May 15, 2024

Primary Completion Date

December 31, 2027

Study Completion Date

December 31, 2030

Conditions
Uterine Cervical Neoplasm
Interventions
RADIATION

SABR VS Intracavitary 3D Brachytherapy

Arm 1 will be the experimental arm and will consist of patients with CC clinical stages IB3-IIIC1 who will be treated with CT/RT with a minimum dose of 45Gy and boost in the case of macroscopic nodes (1.8Gy per fraction from Monday to Friday) with cisplatin and cervical boost with SBRT of 28Gy in 4 fractions administered at least every 40 hours to achieve an EQD210(Gy) at PTV D90% of 83.9Gy. Arm 2 will be the control arm that will consist of patients with CC clinical stages IB3-IIIC1 and will be treated with CT/RT with a minimum dose of 45Gy and boost in the case of macroscopic nodes (1.8Gy per fraction from Monday to Friday) with cisplatin and cervical boost with high-dose-rate 3D brachytherapy with a dose of 28Gy in 4 fractions administered at least every 40 hours to achieve an EQD210(Gy) at point A of 83.9Gy.

Trial Locations (1)

Unknown

RECRUITING

Instituto Nacional de Cancerologia, Mexico City

All Listed Sponsors
collaborator

National Institute of Medical Sciences and Nutrition, Salvador Zubiran

OTHER

lead

National Institute of Cancerología

OTHER_GOV