30
Participants
Start Date
February 3, 2025
Primary Completion Date
September 30, 2026
Study Completion Date
December 31, 2026
Phage Therapy
A 20 mL sterile solution containing one to three individual phage drug substances (TPC) with total strength (potency) 3 x 10\^8 plaque-forming units (PFU), will be administered intravesicularly twice a day (one instillation in the morning and one in the evening \[at least six hours apart\], respectively) for 7 days. The selection of individual phages to include in the TPC are personalized/customized for each participant per phage susceptibility testing to the participant's urinary E. coli (testing is conducted by TAILФR Service Center). Each dose of TPC will be followed with a 10 mL flush of sterile 0.9% saline solution.
Placebo
Sterile 0.9% saline solution also 20 mL, followed with a 10 mL flush of the same solution.
RECRUITING
Michael E. DeBakey VA Medical Center, Houston
Barbara Wells Trautner
OTHER