NCT06557733View on ClinicalTrials.gov

An Investigational Drug (TPST-1495) in Patients With Familial Adenomatous Polyposis

PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

38

Participants

Timeline

Start Date

November 1, 2025

Primary Completion Date

December 17, 2026

Study Completion Date

December 17, 2026

Conditions
Familial Adenomatous Polyposis
Interventions
PROCEDURE

Biopsy Procedure

Undergo biopsy

PROCEDURE

Biospecimen Collection

Undergo blood sample collection

DRUG

EP2/EP4 Antagonist TPST-1495

Given PO

PROCEDURE

Esophagogastroduodenoscopy

Undergo EGD

PROCEDURE

Gastrointestinal Endoscopy

Undergo GI endoscopy

OTHER

Questionnaire Administration

Ancillary studies

Trial Locations (5)

53792

University of Wisconsin Carbone Cancer Center - University Hospital, Madison

55905

Mayo Clinic in Rochester, Rochester

84112

Huntsman Cancer Institute/University of Utah, Salt Lake City

85054

Mayo Clinic Hospital in Arizona, Phoenix

00936

University of Puerto Rico, San Juan

All Listed Sponsors
lead

National Cancer Institute (NCI)

NIH