Utilising AI Analysis of Sounds To prEdict heaRt failurE decOmpensation

Not yet recruitingOBSERVATIONAL
Enrollment

250

Participants

Timeline

Start Date

August 15, 2024

Primary Completion Date

August 15, 2027

Study Completion Date

August 15, 2027

Conditions
Heart Failure
Interventions
OTHER

Height, weight, and BMI

Height, weight measurement and BMI calculation

OTHER

Medical history

Brief medical history including medications/allergies and heart failure related healthcare utilisation over previous 12 months

OTHER

Physical examination

Brief physical examination

DIAGNOSTIC_TEST

Venous blood samples

Venous blood samples, to include WCC, HB, CRP and NTproBNP

OTHER

Resting vital signs

HR, BP, RR, oxygen saturations on air)

DIAGNOSTIC_TEST

Transthoracic echocardiogram

LVEF, IVC collapsibility, LV filling pressure, PA pressure

OTHER

Sound recordings

Sound recordings (voice/cough/chest) recorded with the in-built microphone in a smartphone

DIAGNOSTIC_TEST

Lung ultrasound

Lung ultrasound

OTHER

KCCQ questionnaire

Kansas City Cardiomyopathy Questionnaire

OTHER

ASCEND-HF score

An in-hospital congestion score which risk stratifies patients admitted with worsening heart failure, developed for the Acute study of clinical effectiveness of Nesiritide in decompensated heart failure trial

OTHER

Composite Everest congestion score

A shortened version of the original 18-point score from the EVEREST trial

DIAGNOSTIC_TEST

Bio impedance and total body water measurement

Bio impedance and total body water measurement using TANITA device

All Listed Sponsors
collaborator

University of Cambridge

OTHER

lead

Cambridge University Hospitals NHS Foundation Trust

OTHER

NCT06555757 - Utilising AI Analysis of Sounds To prEdict heaRt failurE decOmpensation | Biotech Hunter | Biotech Hunter