A Single-arm, Phase II Exploratory Study of Sintilimab in Combination With Chemoradiotherapy in Elderly Patients With Locally Advanced Gastric Cancer

PHASE2RecruitingINTERVENTIONAL
Enrollment

40

Participants

Timeline

Start Date

August 6, 2024

Primary Completion Date

December 31, 2026

Study Completion Date

December 31, 2027

Conditions
Gastric Cancer
Interventions
DRUG

Sintilimab

Sintilimab: 200mg iv q3w d1

DRUG

S-1

po d1-d14,q3w; according to body surface area :\<1.5m\^2 40mg/time;1.5\~1.8m\^2 50mg/time;\>1.8m2 60mg/time)

DRUG

Capecitabine

1000mg/m2 Bid po d1-14,q3w,Reduce or discontinue depending on the condition of the subject.

RADIATION

Extraperitoneal radiation therapy

once a day, five times a week, at a dose of 1.8-2 Gy/f, for a total of 45-50.4 Gy. Radiation therapy starts from the first cycle of Sintilimab Injection combined with chemotherapy

Trial Locations (1)

210029

RECRUITING

Jiangsu Province Hospital, Nanjing

All Listed Sponsors
lead

The First Affiliated Hospital with Nanjing Medical University

OTHER