Phase I Trial for Patients w/ Advanced Hematologic Malignancies Undergoing Allogeneic HCT

PHASE1Not yet recruitingINTERVENTIONAL
Enrollment

24

Participants

Timeline

Start Date

January 31, 2026

Primary Completion Date

May 31, 2026

Study Completion Date

December 31, 2026

Conditions
Acute Myeloid LeukemiaAcute Lymphoid LeukemiaMixed Phenotype Acute LeukemiaMyelodysplastic Syndromes
Interventions
DRUG

ORCA-T

On Day 0, participants will receive an infusion of Orca-T HSPCs and Orca-T Tregs. On Day +2 or +3 (between approximately 48 to 72 hours of Day 0), patients will receive an infusion of the Orca-T Tcons. There is no dose escalation or de-escalation planned for the Orca-T investigational product.

Trial Locations (1)

94304

Stanford University, Palo Alto

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Incyte Corporation

INDUSTRY

lead

Stanford University

OTHER