Evaluation of Nasal Non Invasive Ventilation in Management of Neonates With Respiratory Distress Using Lung Ultrasound

NARecruitingINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

November 20, 2024

Primary Completion Date

May 28, 2025

Study Completion Date

November 1, 2025

Conditions
PretermVentilator Lung; Newborn
Interventions
DEVICE

Nasal humidified heated high flow cannula (NHHHC)

Patients in this arm will receive humidified heated high flow using Vapotherm device, USA. Stating with 2 L/min flow and increase gradually till 8L/minute, guided by oxygen requirements.

DEVICE

Nasal intermittent positive pressure ventilation (NIPPV)

Patients in this arm will receive both PEEP (positive end expiratory pressure ) and PIP (peak inspiratory pressure) using SLE 5000/6000 device, UK . Pressures will be adjusted according to severity of respiratory distress.

DEVICE

Nasal continuous positive airway pressure NCPAP

Patients in this arm will receive PEEP (positive end expiratory pressure ), stating from 5 mbar to reach maximally 8 mbar.

DEVICE

lung ultrasound

Lung ultrasound (LUS) machine is a mobile device (Philips HDll XE, USA) with s8-3 probe with a frequency range of 8-3 MHz will be used as ultrasound machine. Throughout the period of non-invasive respiratory support Patient will be monitored by: LUS,Heart rate, Respiratory rate, Mean arterial pressure, Oxygen saturation index, Oxygen index, PaO2, blood gases and Fractional inspired oxygen (Fio2).

Trial Locations (1)

0354

RECRUITING

Alexandria university, Elshattbi hospital, Alexandria

All Listed Sponsors
lead

Alexandria University

OTHER