Zanubrutinib, Obinutuzumab and Lenalidomide in Newly Diagnosed Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL)

PHASE1Active, not recruitingINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

January 1, 2024

Primary Completion Date

December 1, 2025

Study Completion Date

December 1, 2026

Conditions
Chronic Lymphocytic LeukemiaSmall Lymphocytic LymphomaNewly Diagnosed
Interventions
DRUG

Zanubrutinib

160mg bid/d, from C1 to CR and MRD-negative or C24

DRUG

Lenalidomide

From C3 dose escalation, all 3 dose groups climbed from 5 mg/d to 10 mg/d, 15 mg/d, and 20 mg/d respectively, Taking 21 days of medication and 7 days of rest, 1 cycle every 28 days to CR and MRD-negative or C24

DRUG

Obinutuzumab

1000 mg C1, d1/d8/15; 1000 mg C2-6, d1

Trial Locations (1)

Unknown

Institute of Hematology & Blood Diseases Hospital Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin

All Listed Sponsors
lead

Institute of Hematology & Blood Diseases Hospital, China

OTHER

NCT06547944 - Zanubrutinib, Obinutuzumab and Lenalidomide in Newly Diagnosed Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) | Biotech Hunter | Biotech Hunter