DMID 23-0015; Lassa Fever CVD 1000

PHASE1Active, not recruitingINTERVENTIONAL
Enrollment

55

Participants

Timeline

Start Date

January 13, 2025

Primary Completion Date

March 31, 2026

Study Completion Date

March 31, 2026

Conditions
Lassa Fever
Interventions
BIOLOGICAL

LASSARAB+ aPHAD-SEat 700rU

Rabies-Vectored Monovalent Lassa Fever Vaccine (LASSARAB) with 3D-(6- acyl) Phosphorylated Hexaacyl Disaccharides (PHAD)-Stable squalene oil-in-water nanoemulsion (aPHAD-SE) adjuvant administered by IM injection

BIOLOGICAL

HDCV Comparator

Sterile, stable, freeze-dried suspension of rabies virus prepared from strain PM-1503-3M

OTHER

Normal Saline Placebo

Sterile 0.9% sodium chloride for injection, USP, or normal saline, is a sterile, nonpyrogenic, isotonic solution; each mL contains sodium chloride 9 mg

BIOLOGICAL

LASSARAB+ aPHAD-SEat 1400rU

Rabies-Vectored Monovalent Lassa Fever Vaccine (LASSARAB) with 3D-(6- acyl) Phosphorylated Hexaacyl Disaccharides (PHAD)-Stable squalene oil-in-water nanoemulsion (aPHAD-SE) adjuvant administered by IM injection

Trial Locations (1)

21201

University of Maryland, Baltimore, University of Maryland School of Medicine, Center for Vaccine Development and Global Health, Baltimore

All Listed Sponsors
lead

Wilbur Chen, MD, MS

OTHER

NCT06546709 - DMID 23-0015; Lassa Fever CVD 1000 | Biotech Hunter | Biotech Hunter