Epidermal Growth Factor Receptor Inhibition for Keratinopathies

PHASE1/PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

44

Participants

Timeline

Start Date

December 1, 2026

Primary Completion Date

June 30, 2030

Study Completion Date

June 30, 2030

Conditions
Epidermolytic IchthyosisPalmoplantar KeratodermaPachyonychia Congenita
Interventions
DRUG

Erlotinib

Part B will be the dose escalation component, in which the subject will initiate 50 mg erlotinib,8 weeks later escalate to 75 mg, and then 8 weeks later to 100 mg erlotinib pending tolerance after each 8-week period.

Trial Locations (1)

60611

Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago

All Listed Sponsors
collaborator

Yale University

OTHER

lead

Northwestern University

OTHER