336
Participants
Start Date
December 28, 2021
Primary Completion Date
November 30, 2023
Study Completion Date
December 30, 2023
Peginterferon Alfacon-2
Peginterferon Alfacon-2 injection will be weekly subcutaneous injected for 48 weeks. Tenofovir alafenamide Fumarate Tablets(TAF) will be take orally for at least 48 weeks, not more than 72 weeks. Peg-interferon Alfacon-2 and TAF will discontinue when HBsAg levels is less than 0.05 IU/mL and HBV DNA is below 10 IU/mL during 48-72 weeks.
Peginterferon Alfacon-2 placebo
Peginterferon Alfacon-2 placebo injection will be weekly subcutaneous injected for 48 weeks. Tenofovir alafenamide Fumarate Tablets(TAF) will be take orally for at least 48 weeks, not more than 72 weeks. Peg-interferon Alfacon-2 and TAF will discontinue when HBsAg levels is less than 0.05 IU/mL and HBV DNA is below 10 IU/mL during 48-72 weeks.
Beijing Ditan Hospital, Capital Medical University, Beijing
Beijing Youan Hospital, Capital Medical University, Beijing
Peking university Peoole's hospital, Beijing
The First Hospital of Jilin University, Changchun
The second xiangya hospital of central south university, Changsha
Xiangya Hospital Central South University, Changsha
Sichuan Provincial People's Hospital, Chengdu
The Peoole's hospital of Chizhou, Chizhou
The First Affiliated Hospital of Army Medical University, Chongqing
The Second Affiliated Hospital of Chongqing Medical University, Chongqing
Mengchao hepatobiliary hospital of Fujian medical university, Fuzhou
The First Affiliated Hospital of Fujian Medical University, Fuzhou
Guangzhou Eighth People's Hospital, Guangzhou
The Fourth Affiliated Hospital of Harbin Medical University, Harbin
Heze Municipal Hospital, Heze
Shandong Public Health Clinical Center, Jinan
Hebei petro china central hospital, Langfang
The First Affiliated Hospital of Nanchang University, Nanchang
The Second Hospital of Nanjing, Nanjing
Pingxiang NO.2 People's Hospital, Pingxiang
Qingdao Municipal Hospital, Qingdao
The Peoole's hospital of Qingyuan, Qingyuan
The Sixth People's Hospital of Shenyang, Shenyang
Shijiazhuang Hospital of Traditional Chinese Medicine, Shijiazhuang
The Third Hospital of Hebei Medical University, Shijiazhuang
The Second People's Hospital of Tianjin, Tianjin
Tianjin Third Central Hospital, Tianjin
Tongji medical college of Hust, Wuhan
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan
The Second Affiliated Hospital of Xian Jiaotong University, Xi'an
The third affiliated hospital of Xingxiang medical university, Xingxiang
Yanbian University Hospital, Yanbian
Henan People's Hospital, Zhengzhou
The Sixth People's Hospital of Zhengzhou, Zhengzhou
Beijing Kawin Technology Share-Holding Co., Ltd.
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