NCT06544018 - Circadian Rhythm Deregulation in Patients With CAPS | Biotech Hunter

Enrollment

Participants

Timeline

Start Date

September 1, 2025

Primary Completion Date

September 1, 2028

Study Completion Date

November 1, 2028

Conditions

Cryopyrin Associated Periodic SyndromeFamilial Cold UrticariaMuckle-Wells SyndromeCINCA Syndrome

Interventions

GENETIC

Genetic analysis of NLRP3

Blood test for genetic analysis of NLRP3

DEVICE

Circadian rhythm measurement

Wear a Withings Pulse HR (heart rate) actigraphic watch 24 hours a day for 1 month to define circadian rhythm

BIOLOGICAL

Saliva sampling

Saliva sampling for salivary melatonin determination

OTHER

Questionnaire

Questionnaire to determine chronotype

OTHER

AIDAI score

Disease activity score using AIDAI score (only for patients in the CAPS group) AIDAI : AUTO-INFLAMMATORY DISEASE ACTIVITY INDEX

BIOLOGICAL

Blood sampling

"1. Inflammatory cytokines measurement : IL1-beta (Interleukin-1) and IL-18.~2. Molecular characterization of circadian clock signaling pathways"

Trial Locations (6)

Hôpital Claude Huriez (CHU de Lille), Lille

Hôpital de la Croix-Rousse (HCL), Lyon

Hôpital Edouard Herriot (HCL), Lyon

Hôpital Femme-Mère-Enfant (HCL), Bron

Hôpital Tenon (AP-HP), Paris

Hôpital Kremlin-Bicêtre (AP-HP), Paris

All Listed Sponsors

lead

Hospices Civils de Lyon

OTHER