NCT06543576 - External Beam Radiation Therapy and Brachytherapy With Chemotherapy and Immunotherapy for the Treatment of Stage IVB Cervical Cancer | Biotech Hunter

Enrollment

Participants

Timeline

Start Date

July 29, 2025

Primary Completion Date

January 31, 2031

Study Completion Date

January 31, 2032

Conditions

Cervical AdenocarcinomaCervical Adenosquamous CarcinomaCervical Squamous Cell CarcinomaStage IVB Cervical Cancer American Joint Committee on Cancer (AJCC) v8

Interventions

BIOLOGICAL

Bevacizumab

Given IV

PROCEDURE

Biospecimen Collection

Undergo blood sample collection

RADIATION

Brachytherapy

Undergo brachytherapy

DRUG

Cisplatin

Given IV

RADIATION

External Beam Radiation Therapy

Undergo EBRT

DRUG

Paclitaxel

Given IV

BIOLOGICAL

Pembrolizumab

Given IV

OTHER

Questionnaire Administration

Ancillary study

Trial Locations (4)

22908

NOT_YET_RECRUITING

University of Virginia Cancer Center, Charlottesville

73104

NOT_YET_RECRUITING

University of Oklahoma Health Sciences Center, Oklahoma City

90095

RECRUITING

UCLA / Jonsson Comprehensive Cancer Center, Los Angeles

96960

NOT_YET_RECRUITING

University of California San Diego (UCSD), San Diego

All Listed Sponsors

collaborator

Merck Sharp & Dohme LLC

INDUSTRY

lead

Jonsson Comprehensive Cancer Center

OTHER