32
Participants
Start Date
August 1, 2024
Primary Completion Date
January 13, 2025
Study Completion Date
January 13, 2025
Lactulose/Mannitol Ratio Test
To test for gut permeability, Urine collected over 8hrs after ingestion of lactulose/mannitol drink.
Serum biomarkers of intestinal permeability
Phlebotomy and subsequent lab tests to analyse concentration of LPS, LPB, sCD14, Zonulin and Occludin.
Rome IV questionnaire
Diagnositic questionnaire for IBS-D
Irritable bowel severity scoring system
Questionnaire to determine severity of abdominal and bowel symptoms
Bowel Habit diary
Assess bowel habit at baseline and changes in bowel habit over the study
3 day dietary record
Used to verify compliance to exclusion criteria #5.
NCT and NFT
N-transcaffeoyltyramine and N-transferuloyltyramine supplement taken once per day.
Placebo
Placebo supplement taken once per day.
The Functional Gut Clinic, London
The Functional Gut Clinic, Manchester
Dr Anthony Hobson
OTHER