A Study of Sequential Therapy With Daplusiran/Tomligisiran (DAP/TOM) Followed by Bepirovirsen in Participants Living With Chronic Hepatitis B (CHB)

PHASE2Active, not recruitingINTERVENTIONAL
Enrollment

283

Participants

Timeline

Start Date

November 11, 2024

Primary Completion Date

May 31, 2027

Study Completion Date

May 31, 2027

Conditions
Chronic Hepatitis B Virus InfectionHepatitis B
Interventions
DRUG

Daplusiran/Tomligisiran Dose Level 1

Daplusiran/Tomligisiran dose level 1 will be administered

DRUG

Daplusiran/Tomligisiran Dose Level 2

Daplusiran/Tomligisiran dose level 2 will be administered

DRUG

Bepirovirsen

Bepirovirsen will be administered

DRUG

Placebo

Placebo will be administered

Trial Locations (81)

333

GSK Investigational Site, Tau-Yuan

404

GSK Investigational Site, Taichung

807

GSK Investigational Site, Kaohsiung City

824

GSK Investigational Site, Kaohsiung City

1000

GSK Investigational Site, Brussels

1023

GSK Investigational Site, Auckland

1459

GSK Investigational Site, Reiger Park

2025

GSK Investigational Site, Papatoetoe Auckland

2145

GSK Investigational Site, Westmead

2193

GSK Investigational Site, Johannesburg

2650

GSK Investigational Site, Edegem

3065

GSK Investigational Site, Fitzroy

9000

GSK Investigational Site, Ghent

10029

GSK Investigational Site, New York

10439

GSK Investigational Site, Berlin

10676

GSK Investigational Site, Athens

10787

GSK Investigational Site, Berlin

11527

GSK Investigational Site, Athens

13008

GSK Investigational Site, Marseille

15355

GSK Investigational Site, Ansan

19104

GSK Investigational Site, Philadelphia

24080

GSK Investigational Site, León

24127

GSK Investigational Site, Bergamo

28041

GSK Investigational Site, Madrid

30625

GSK Investigational Site, Hanover

31059

GSK Investigational Site, Toulouse

35131

GSK Investigational Site, Padua

37007

GSK Investigational Site, Salamanca

39008

GSK Investigational Site, Santander

46026

GSK Investigational Site, Valencia

47392

GSK Investigational Site, Busan

48149

GSK Investigational Site, Münster

49241

GSK Investigational Site, Pusan

50134

GSK Investigational Site, Florence

55415

GSK Investigational Site, Minneapolis

56124

GSK Investigational Site, Pisa

69004

GSK Investigational Site, Lyon

80131

GSK Investigational Site, Napoli

87042

GSK Investigational Site, Limoges

92118

GSK Investigational Site, Clichy

94010

GSK Investigational Site, Créteil

94115

GSK Investigational Site, San Francisco

95128

GSK Investigational Site, San Jose

100050

GSK Investigational Site, Beijing

119074

GSK Investigational Site, Singapore

169608

GSK Investigational Site, Singapore

200040

GSK Investigational Site, Shanghai

510630

GSK Investigational Site, Guangzhou

610072

GSK Investigational Site, Chengdu

49060-010

GSK Investigational Site, Aracaju

80810-050

GSK Investigational Site, Curitiba

69040-000

GSK Investigational Site, Manaus

05403-000

GSK Investigational Site, São Paulo

T2N 4Z6

GSK Investigational Site, Calgary

K1H8L6

GSK Investigational Site, Ottawa

M5G 2C4

GSK Investigational Site, Toronto

H4A 3J1

GSK Investigational Site, Montreal

Unknown

GSK Investigational Site, Pokfulam

GSK Investigational Site, Shatin

GSK Investigational Site, Milan

00161

GSK Investigational Site, Roma

270-1694

GSK Investigational Site, Chiba

006-8555

GSK Investigational Site, Hokkaido

053-8506

GSK Investigational Site, Hokkaido

660-8550

GSK Investigational Site, Hyōgo

760-8557

GSK Investigational Site, Kagawa

761-0793

GSK Investigational Site, Kagawa

860-8556

GSK Investigational Site, Kumamoto

862-8655

GSK Investigational Site, Kumamoto

540-0006

GSK Investigational Site, Osaka

565-0871

GSK Investigational Site, Osaka

180-8610

GSK Investigational Site, Tokyo

409-3898

GSK Investigational Site, Yamanashi

07061

GSK Investigational Site, Seoul

138-736

GSK Investigational Site, Seoul

08035

GSK Investigational Site, Barcelona

08036

GSK Investigational Site, Barcelona

E1 8PR

GSK Investigational Site, London

SE5 9RS

GSK Investigational Site, London

SW17 0QT

GSK Investigational Site, London

TS4 3BW

GSK Investigational Site, Middlesbrough

Sponsors

Lead Sponsor

All Listed Sponsors
lead

GlaxoSmithKline

INDUSTRY