NEO-BLAST: Neoadjuvant Therapy for Bladder Cancer Followed by Active Surveillance vs Treatment

PHASE2/PHASE3RecruitingINTERVENTIONAL
Enrollment

688

Participants

Timeline

Start Date

July 28, 2025

Primary Completion Date

December 31, 2028

Study Completion Date

December 31, 2030

Conditions
Muscle-Invasive Bladder Carcinoma
Interventions
PROCEDURE

Active Surveillance

Participant found to have a cCR will be randomized to either standard of care or investigational active surveillance.

PROCEDURE

Control arm - Definitive bladder treatment

Standard of care, consisting of radical cystectomy or chemo-radiation of the bladder

Trial Locations (1)

V5Z 1M9

RECRUITING

Vancouver Prostate Centre, Vancouver

All Listed Sponsors
collaborator

University of British Columbia

OTHER

collaborator

Canadian Institutes of Health Research (CIHR)

OTHER_GOV

lead

Peter Black

OTHER

NCT06537154 - NEO-BLAST: Neoadjuvant Therapy for Bladder Cancer Followed by Active Surveillance vs Treatment | Biotech Hunter | Biotech Hunter