Safety and Efficacy of Anti-CD20/CD30 CAR-T Cells in Subjects with Relapsed/Refractory Lymphoma

EARLY_PHASE1RecruitingINTERVENTIONAL
Enrollment

9

Participants

Timeline

Start Date

August 24, 2023

Primary Completion Date

September 1, 2025

Study Completion Date

September 1, 2026

Conditions
Relapsed/Refractory Lymphoma
Interventions
GENETIC

anti-CD20/CD30-CAR-T cells

"Each subject will be infused with single dose of anti-CD20/CD30-CAR-T cells. A classic 3+3 dose escalation will be employed."

DRUG

Fludarabine

Fludarabine will be given at a dose of 25 mg/m2/day intravenously (IV) for 3 days prior to the infusion of anti-CD20/CD30-CAR-T cells.

DRUG

Cyclophosphamide

Cyclophosphamide will be given at a dose of 250 mg/m2/day intravenously (IV) for 3 days prior to the infusion of anti-CD20/CD30-CAR-T cells.

Trial Locations (1)

230022

RECRUITING

The First Affiliated Hospital of Anhui Medical University, Hefei

All Listed Sponsors
lead

Shanghai First Song Biotechnology Co., LTD

INDUSTRY