Anti-CD19-CAR-T Cells in Subjects With Relapsed/Refractory B Cell Malignancies

EARLY_PHASE1RecruitingINTERVENTIONAL
Enrollment

9

Participants

Timeline

Start Date

August 24, 2023

Primary Completion Date

September 1, 2025

Study Completion Date

September 1, 2026

Conditions
B-Cell Malignancy
Interventions
GENETIC

Anti-CD19-CAR-T cells

"Each subject will be infused with single dose of anti-CD19-CAR-T cells.~A classic 3+3 dose escalation will be employed."

DRUG

Fludarabine

Fludarabine will be given at a dose of 25 mg/m2/day intravenously (IV) for 3 days prior to anti-CD19-CAR-T cells infusion.

DRUG

Cyclophosphamide

Cyclophosphamide will be given at a dose of 250 mg/m2/day intravenously (IV) for 3 days prior to anti-CD19-CAR-T cells infusion.

Trial Locations (1)

230022

RECRUITING

The First Affiliated Hospital of Anhui Medical University, Hefei

All Listed Sponsors
collaborator

The First Affiliated Hospital of Anhui Medical University

OTHER

lead

Shanghai First Song Biotechnology Co., LTD

INDUSTRY