Comparison of VA (Venetoclax, Azacitidine), VACl (VA, Cladribine), VACh (VA, Chidamide), and Alternating VACl/VACh in Newly Diagnosed Acute Myeloid Leukemia

PHASE2RecruitingINTERVENTIONAL
Enrollment

172

Participants

Timeline

Start Date

July 29, 2024

Primary Completion Date

August 1, 2027

Study Completion Date

August 1, 2028

Conditions
Acute Myeloid Leukemia, AdultNewly Diagnosed
Interventions
DRUG

VACl

Azacitidine:75mg/m2 Subcutaneous daily for 7 days Venetoclax: orally once daily (100 mg d1, 200mg d2, 400mg d3-28) Cladribine: 5mg/m2 IV over approximately 1 to 2 hours, daily on days 1-3.

DRUG

VACh

Azacitidine: 75mg/m2 Subcutaneous daily for 7 days Venetoclax: orally once daily (100mg d1, 200mg d2, 400mg d3-28) Chidamide: 10mg orally daily for 12 days

DRUG

VACl Alternating With VACh

"VACl:~Azacitidine:75mg/m2 Subcutaneous daily for 7 days Venetoclax: orally once daily (100 mg d1, 200mg d2, 400mg d3-28) Cladribine: 5mg/m2 IV over approximately 1 to 2 hours, daily on days 1-3.~VACh:~Azacitidine: 75mg/m2 Subcutaneous daily for 7 days Venetoclax: orally once daily (100mg d1, 200mg d2, 400mg d3-28) Chidamide: 10mg orally daily for 12 days"

DRUG

VA

Azacitidine: 75mg/m2 Subcutaneous (SC) daily for 7 days Venetoclax: orally once daily (100mg d1, 200mg d2, 400mg d3-28).

Trial Locations (1)

215006

RECRUITING

The First Affliated Hospital of Soochow University, Suzhou

All Listed Sponsors
collaborator

Jining Medical University

OTHER

collaborator

Qilu Hospital of Shandong University

OTHER

collaborator

The Affiliated Hospital of Qingdao University

OTHER

collaborator

The First Affiliated Hospital of Anhui Medical University

OTHER

collaborator

Tongji Hospital

OTHER

collaborator

The First Affiliated Hospital of Bengbu Medical University

OTHER

lead

The First Affiliated Hospital of Soochow University

OTHER