60
Participants
Start Date
August 25, 2024
Primary Completion Date
January 31, 2026
Study Completion Date
February 28, 2026
Esketamine(Continuous infusion)
Continuous intravenous infusion of esketamine at a dose of 0.2 mg/(kg · h). Collect resting-state EEG data and NRS scores 40 minutes after administration.
Remifentanil (Target-Controlled Infusion)
The plasma drug concentrations of remifentanil were set at 0.5 ng/ml, 1 ng/ml, and 1.5 ng/ml. After each plasma drug concentration reached a steady state, the NRS scores were assessed, and resting-state EEG was recorded for at least 5 minutes.
Flurbiprofen (Single intravenous injection)
Single intravenous injection of Flurbiprofen at a dose of 100 mg. Collect resting-state EEG data and NRS scores 10 minutes after administration.
Spinal Cord Stimulation
Collect resting-state EEG data and NRS scores with the spinal cord stimulator both turned off and on.
No intervention
Collect resting-state EEG data and NRS scores.
Beijing Tiantan Hospital, Beijing
Beijing Tiantan Hospital
OTHER