Personalized Cancer Vaccine (PCV) Strategy in Patients With Solid Tumors and Molecular Residual Disease

PHASE1RecruitingINTERVENTIONAL
Enrollment

16

Participants

Timeline

Start Date

March 20, 2025

Primary Completion Date

October 31, 2028

Study Completion Date

March 31, 2033

Conditions
Muscle-Invasive Bladder Carcinoma
Interventions
BIOLOGICAL

Synthetic long peptide personalized cancer vaccine

Neoantigen vaccines will be provided on a patient-specific basis

DRUG

Poly ICLC

Poly-ICLC will be supplied by Oncovir, Inc.

DEVICE

Signatera assay

Signatera is a clinically validated, personalized, tumor-informed, multiplex-PCR and next-generation sequencing (NGS) based clinical trial assay targeting 16 tumor-specific mutations. It is intended for the detection of ctDNA isolated from anticoagulated peripheral whole blood from post-surgical patients previously diagnosed with localized or advanced solid tumors to aid physician assessment and treatment decision-making, together with other clinical factors

Trial Locations (1)

63110

RECRUITING

Washington University School of Medicine, St Louis

Sponsors

Collaborators (1)

All Listed Sponsors
collaborator

Natera, Inc.

INDUSTRY

lead

Washington University School of Medicine

OTHER

NCT06529822 - Personalized Cancer Vaccine (PCV) Strategy in Patients With Solid Tumors and Molecular Residual Disease | Biotech Hunter | Biotech Hunter