NCT06525389 - Liposomal Amphotericin B and Flucytosine Antifungal Strategy for Talaromycosis (LAmB-FAST) | Biotech Hunter

Enrollment

428

Participants

Timeline

Start Date

December 1, 2025

Primary Completion Date

July 1, 2030

Study Completion Date

July 1, 2031

Conditions

Talaromycosis

Interventions

DRUG

Liposomal Amphotericin B (LAmB)

Antifungal dosed at 10 mg/kg/day IV x one single dose.

DRUG

Flucytosine (5FC)

Antifungal dosed at 25mg/kg oral 3x daily.

DRUG

Flucytosine (5FC) placebo pill

Similar in appearance to flucytosine. Also dosed at 25mg/kg oral 3x daily.

DRUG

Deoxycholate Amphotericin B (DAmB)

Antifungal dosed at 0.7 mg/kg/day IV x 2 weeks.

Trial Locations (5)

Hospital for Tropical Diseases, Ho Chi Minh City

Pham Ngoc Thach University of Medicine, Ho Chi Minh City

Duke University Medical Center, Durham

Bach Mai Hospital, Hanoi

National Hospital for Tropical Diseases, Hanoi