A Study to Evaluate the Effect of Venetoclax on Participants Receiving a Covalent Bruton's Tyrosine Kinase Inhibitor (cBTKi) for First-line Chronic Lymphocytic Leukemia (1L CLL) to Achieve Deep Durable Remissions to Allow Off-treatment Period.

PHASE2RecruitingINTERVENTIONAL
Enrollment

110

Participants

Timeline

Start Date

August 9, 2024

Primary Completion Date

February 8, 2027

Study Completion Date

February 8, 2028

Conditions
Chronic Lymphocytic Leukemia
Interventions
DRUG

Venetoclax

Venetoclax tablets will be administered as per the schedule specified in the arm.

DRUG

cBTKi Monotherapy

Commercially available cBTKi (ibrutinib or acalabrutinib, or zanubrutinib) will be administered in accordance with its prescribing label.

Trial Locations (21)

30607

WITHDRAWN

University Cancer & Blood Center, LLC, Athens

37203

RECRUITING

Tennessee Oncology - Midtown, Nashville

37404

RECRUITING

Tennessee Oncology, PLLC - Chattanooga, Chattanooga

43210

RECRUITING

Ohio State University, Columbus

46804

RECRUITING

Fort Wayne Medical Oncology and Hematology, Inc, Fort Wayne

53226

RECRUITING

Medical College of Wisconsin, Milwaukee

68803

RECRUITING

Nebraska Cancer Specialists St Francis - Grand Island, Grand Island

72762

RECRUITING

Highlands Oncology Group, Springdale

75702

RECRUITING

Texas Oncology- Northeast Texas, Tyler

77030

RECRUITING

MD Anderson Cancer Center, Houston

87401

COMPLETED

San Juan Oncology Associates, PC, Farmington

80012-5405

RECRUITING

Rocky Mountain Cancer Centers (Aurora) - USOR, Aurora

32256-6932

RECRUITING

Cancer Specialists of North Florida, Jacksonville

50314-3030

RECRUITING

Mission Blood and Cancer - MercyOne Cancer Center, Des Moines

20817-1915

RECRUITING

American Oncology Partners of Maryland, PA, Bethesda

02215-5418

RECRUITING

Dana-Farber Cancer Institute - Hematologic Oncology Treatment Center, Boston

68130-2042

RECRUITING

Nebraska Cancer Specialists, Omaha

08816-4096

RECRUITING

Astera Cancer Care East Brunswick, East Brunswick

45236-2725

RECRUITING

Oncology Hematology Care Inc - Cincinnati - USOR, Cincinnati

97401-6043

RECRUITING

Oncology Associates of Oregon, P.C., Eugene

97504-8332

RECRUITING

Asante Rogue Regional Medical Center, Medford

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Genentech, Inc.

INDUSTRY