A Randomized Phase II Study Of Bruton Tyrosine Kinase Inhibitor With Or Without Venetoclax In Veterans With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)

PHASE2RecruitingINTERVENTIONAL
Enrollment

100

Participants

Timeline

Start Date

October 1, 2025

Primary Completion Date

June 30, 2030

Study Completion Date

December 31, 2030

Conditions
Chronic Lymphocytic LeukemiaSmall Lymphocytic Lymphoma
Interventions
DRUG

Venetoclax

VENCLEXTA is indicated for the treatment of patients with chronic lymphocytic leukemia (CLL) with 17p deletion, as detected by an FDA approved test, who have received at least one prior therapy.

DRUG

Ibrutinib, Acalabrutinib, Zanubrutinib

IMBRUVICA is a kinase inhibitor Acalabrutinib is a selective, irreversible small molecule inhibitor of BTK. Zanubrutinib is BTK inhibitors

Trial Locations (4)

94121-1563

RECRUITING

San Francisco VA Medical Center, San Francisco, CA, San Francisco

64128-2226

RECRUITING

Kansas City VA Medical Center, Kansas City, MO, Kansas City

27705-3875

RECRUITING

Durham VA Medical Center, Durham, NC, Durham

98108-1532

RECRUITING

VA Puget Sound Health Care System Seattle Division, Seattle, WA, Seattle

All Listed Sponsors
lead

VA Office of Research and Development

FED