1,300
Participants
Start Date
October 31, 2024
Primary Completion Date
October 31, 2027
Study Completion Date
October 31, 2027
Βeta-Blockers discontinued (with tapering)
"The experimental group will undergo discontinuation of their beta-blockers treatment during the study period.~The tapering of beta-blocker will start on the day after randomisation and is based on a reduction by half-dose every 48 hours (1/2 maximally recommended dose for 48 hours, then ¼ maximally recommended dose for 48 hours) until reaching the minimal recommended dosage (1/8 maximally recommended dose) for 48 hours before complete interruption of treatment. Consequently, the tapering will not be needed in patients already receiving the minimal recommended dosage (i.e., 1/8 dose) at inclusion, and these patients will be instructed to stop taking beta-blockers the day after randomisation."
Hôpital Européen Georges Pompidou, Paris
Assistance Publique - Hôpitaux de Paris
OTHER