NCT06518057View on ClinicalTrials.gov

Hippocampal Avoidance in Craniospinal Irradiation for the Treatment of Leptomeningeal Metastases From Breast Cancer or Non-small Cell Lung Cancer

PHASE2RecruitingINTERVENTIONAL
Enrollment

22

Participants

Timeline

Start Date

March 3, 2025

Primary Completion Date

June 30, 2026

Study Completion Date

June 30, 2027

Conditions
Anatomic Stage IV Breast Cancer AJCC v8Metastatic Breast CarcinomaMetastatic Lung Non-Small Cell CarcinomaMetastatic Malignant Neoplasm in the LeptomeningesStage IV Lung Cancer AJCC v8
Interventions
PROCEDURE

Biospecimen Collection

Undergo CSF sample collection

PROCEDURE

Computed Tomography

Undergo PET/CT and/or CT

OTHER

Electronic Health Record Review

Ancillary studies

PROCEDURE

Lumbar Puncture

Undergo lumbar puncture

PROCEDURE

Magnetic Resonance Imaging

Undergo MRI

PROCEDURE

Positron Emission Tomography

Undergo PET/CT

RADIATION

Proton Beam Craniospinal Irradiation

Undergo proton CSI

OTHER

Survey Administration

Ancillary studies

RADIATION

Volume Modulated Arc Therapy

Undergo photon VMAT CSI

PROCEDURE

Hippocampal-Avoidance Craniospinal Irradiation

Undergo HA

Trial Locations (1)

98109

RECRUITING

Fred Hutch/University of Washington Cancer Consortium, Seattle

All Listed Sponsors
lead

University of Washington

OTHER