NAC for Hematopoietic Recovery in SAA

PHASE2Not yet recruitingINTERVENTIONAL
Enrollment

30

Participants

Timeline

Start Date

July 25, 2024

Primary Completion Date

December 31, 2024

Study Completion Date

July 1, 2025

Conditions
Aplastic Anemia
Interventions
DRUG

N Acetyl L Cysteine

For subjects in the experimental intervention arm (NAC group), if the patients met the inclusion criteria on day 14 before conditioning, they received NAC from day 14 before conditioning until day +60 post-HSCT. The initial dose of NAC was 400mg orally three times daily (TID). In cases of grade 3 or worse AEs (not including hematologic recovery), dose modifications including dose reductions or interruptions were permitted at the physician's discretion. After the resolution of AEs, the dose was re-escalated from to 400mg TID.

All Listed Sponsors
lead

Peking University People's Hospital

OTHER