Befotertinib and Icotinib for NSCLC With Uncommon EGFR Mutations

PHASE2RecruitingINTERVENTIONAL
Enrollment

23

Participants

Timeline

Start Date

July 17, 2024

Primary Completion Date

July 30, 2026

Study Completion Date

December 24, 2027

Conditions
Non-small Cell Lung Cancer MetastaticEGFR G719XEGFR L861QEGFR S768I
Interventions
DRUG

Icotinib

An orally first-generation EGFR inhibitior.

DRUG

Befotertinib

An orally available, irreversible, third-generation,mutant-selective epidermal growth factor receptor(EGFR)inhibitor. Befotertinib combine with icotinib means that both drugs will be given together until disease progression or meet the discontinuation criteria.

Trial Locations (1)

510060

RECRUITING

Sun Yat-sen University Cancer Center, Guangzhou

All Listed Sponsors
lead

Sun Yat-sen University

OTHER