A Study of HB-202/HB-201 With Pembrolizumab in Patients With HPV16+ Recurrent/Metastatic Oropharyngeal Cancer

PHASE2/PHASE3WithdrawnINTERVENTIONAL
0
Timeline

Start Date

December 31, 2024

Primary Completion Date

November 30, 2029

Study Completion Date

April 30, 2032

Conditions
Oropharyngeal Squamous Cell Carcinoma Recurrent
Interventions
DRUG

HB-202/HB-201 alternating 2-vector therapy

Intravenous administration of HB-202 alternating with HB-201, with the first 2 treatment cycles administered every 3 weeks and then every 6 weeks from the third treatment cycle onwards.

DRUG

Placebo

Intravenous administration of matched placebo for HB-202 alternating with matched placebo for HB-201, with the first 2 treatment cycles administered every 3 weeks and then every 6 weeks from the third treatment cycle onwards.

DRUG

Pembrolizumab

Intravenous administration of pembrolizumab, with the first 2 treatment cycles administered at a dosage of 200 mg every 3 weeks and then every 6 weeks from the third treatment cycle onwards administered at a dosage of 400 mg.

Sponsors
All Listed Sponsors
lead

Hookipa Biotech GmbH

INDUSTRY

NCT06513884 - A Study of HB-202/HB-201 With Pembrolizumab in Patients With HPV16+ Recurrent/Metastatic Oropharyngeal Cancer | Biotech Hunter | Biotech Hunter