Intraosseous Morphine Administration During Anterior Cruciate Ligament Reconstruction

PHASE4RecruitingINTERVENTIONAL
Enrollment

84

Participants

Timeline

Start Date

August 19, 2024

Primary Completion Date

July 31, 2027

Study Completion Date

July 31, 2029

Conditions
Anterior Cruciate Ligament TearAnterior Cruciate Ligament InjuriesAnterior Cruciate Ligament Rupture
Interventions
DRUG

Intraosseous Morphine

More recently, intraosseous infusion of analgesics and antibiotics has gained traction in the total joint arthroplasty literature. In knee arthroplasty patients, the combination of a spine and adductor canal block with an intraosseous infusion of morphine into the tibial tubercle prior to incision yielded lower pain in the immediate postoperative period and at 2 weeks, less pain medication use, and significantly better patient-reported outcomes while also reducing systemic opioid exposure in the early postoperative period compared to the spine and adductor block alone.3 No study to date in the available literature has evaluated the efficacy of intraosseous morphine infusion in managing acute postoperative pain in patients undergoing ACL reconstruction with bone-patellar tendon-bone autograft, so that is the intended evaluation point with this project.

Trial Locations (1)

77030

RECRUITING

Houston Methodist Research Institute, Houston

All Listed Sponsors
lead

The Methodist Hospital Research Institute

OTHER