A Study of BH-30236 in Relapsed/ Refractory Acute Myelogenous Leukemia and Higher Risk Myelodysplastic Syndrome

PHASE1RecruitingINTERVENTIONAL
Enrollment

170

Participants

Timeline

Start Date

June 19, 2024

Primary Completion Date

June 30, 2026

Study Completion Date

June 30, 2027

Conditions
LeukemiaLeukemia, MyeloidLeukemia, Myeloid, AcutePreleukemiaMyelodysplastic SyndromesRefractory Acute Myeloid Leukemia
Interventions
DRUG

BH-30236

BH-30236 will be provided as either a 5 mg, 15 mg or 30 mg tablet. Participants will take BH-30236 tablets orally depending on their dose level assignment.

DRUG

Venetoclax

Venetoclax will be provided as 10 mg, 50 mg or 100 mg tablets. Participants will take venetoclax orally per label instructions.

Trial Locations (13)

10065

RECRUITING

Memorial Sloan Kettering Cancer Center, New York

14263

RECRUITING

Roswell Park Cancer Institute, Buffalo

33136

RECRUITING

Sylvester Comprehensive Cancer Center, Miami

33612

RECRUITING

Moffitt Cancer Center, Tampa

37203

RECRUITING

Sarah Cannon Research Institute, Nashville

43210

RECRUITING

The Ohio State University Wexner Medical Center - James Cancer Hosp, Columbus

53792

RECRUITING

University of Wisconsin Clinical Science Center, Madison

60611

RECRUITING

Northwestern Medicine - Northwestern Memorial Hospital Galter Pavilion, Chicago

77030

RECRUITING

The University of Texas M.D. Anderson Cancer Center, Houston

90095

RECRUITING

University of California Los Angeles, Los Angeles

91010

RECRUITING

City of Hope Medical Center, Duarte

94304

RECRUITING

Stanford Cancer Center, Palo Alto

98109

RECRUITING

Fred Hutchinson Cancer Center, Seattle

Sponsors
All Listed Sponsors
lead

BlossomHill Therapeutics

INDUSTRY