A Study to Evaluate the Efficacy and Safety of Frexalimab, Brivekimig, or Rilzabrutinib in Participants Aged 16 to 75 Years With Primary Focal Segmental Glomerulosclerosis or Minimal Change Disease

PHASE2RecruitingINTERVENTIONAL
Enrollment

84

Participants

Timeline

Start Date

December 19, 2024

Primary Completion Date

December 23, 2026

Study Completion Date

February 16, 2028

Conditions
Focal Segmental GlomerulosclerosisGlomerulonephritis Minimal Lesion
Interventions
DRUG

frexalimab

frexalimab treatment

DRUG

brivekimig

brivekimig treatment

DRUG

rilzabrutinib

rilzabrutinib treatment

DRUG

placebo

placebo treatment

Trial Locations (61)

1083

RECRUITING

Investigational Site Number : 3480001, Budapest

2605

RECRUITING

Investigational Site Number : 0360003, Garran

3050

RECRUITING

Investigational Site Number : 0360001, Parkville

10002

RECRUITING

Investigational Site Number : 1580002, Taipei

10032

RECRUITING

Investigational Site Number : 8400001, New York

10117

RECRUITING

Investigational Site Number : 2760002, Berlin

12808

RECRUITING

Investigational Site Number : 2030001, Prague

14004

RECRUITING

Investigational Site Number : 7240002, Córdoba

14080

RECRUITING

Investigational Site Number : 4840001, Mexico City

25123

RECRUITING

Investigational Site Number : 3800001, Brescia

27599

RECRUITING

Investigational Site Number : 8400021, Chapel Hill

30625

RECRUITING

Investigational Site Number : 2760003, Hanover

35233

RECRUITING

Investigational Site Number : 8400007, Birmingham

38039

RECRUITING

Investigational Site Number : 7920002, Kayseri

41013

RECRUITING

Investigational Site Number : 7240005, Seville

41100

RECRUITING

Investigational Site Number : 7920001, Kocaeli

46026

RECRUITING

Investigational Site Number : 7240003, Valencia

48109

RECRUITING

Investigational Site Number : 8400010, Ann Arbor

50134

RECRUITING

Investigational Site Number : 3800002, Florence

55435

RECRUITING

Investigational Site Number : 8400019, Edina

60521

RECRUITING

Investigational Site Number : 8400017, Hinsdale

60611

RECRUITING

Investigational Site Number : 8400014, Chicago

64460

RECRUITING

Investigational Site Number : 4840003, Monterrey

75015

RECRUITING

Investigational Site Number : 2500001, Paris

75204

RECRUITING

Investigational Site Number: 8400024, Dallas

77054

RECRUITING

Investigational Site Number: 8400016, Houston

77900

RECRUITING

Investigational Site Number : 2030002, Olomouc

79902

RECRUITING

Investigational Site Number : 8400005, El Paso

80131

RECRUITING

Investigational Site Number : 3800003, Naples

89107

RECRUITING

Investigational Site Number: 8400018, Las Vegas

92868

RECRUITING

Investigational Site Number : 8400015, Orange

94000

RECRUITING

Investigational Site Number : 2500002, Créteil

94143

RECRUITING

Investigational Site Number : 8400012, San Francisco

97401

RECRUITING

Investigational Site Number : 7030003, Banská Bystrica

100034

RECRUITING

Investigational Site Number : 1560001, Beijing

200080

RECRUITING

Investigational Site Number : 1560004, Shanghai

404332

RECRUITING

Investigational Site Number : 1580001, Taichung

610072

RECRUITING

Investigational Site Number : 1560003, Chengdu

4781151

RECRUITING

Investigational Site Number : 1520003, Temuco

8320000

RECRUITING

Investigational Site Number : 1520002, Santiago

C1425ASG

RECRUITING

Investigational Site Number : 0320001, CABA

X5016KET

RECRUITING

Investigational Site Number : 0320002, Córdoba

04038-002

RECRUITING

Investigational Site Number : 0760002, São Paulo

05403-010

RECRUITING

Investigational Site Number: 0760001, São Paulo

N6A 5A5

RECRUITING

Investigational Site Number : 1240002, London

H1T 2M4

RECRUITING

Investigational Site Number : 1240001, Montreal

G1R 2J6

RECRUITING

Investigational Site Number : 1240006, Québec

115 27

RECRUITING

Investigational Site Number : 3000002, Athens

715 00

RECRUITING

Investigational Site Number : 3000001, Heraklion Crete

1105 AZ

RECRUITING

Investigational Site Number : 5280001, Amsterdam

92-213

RECRUITING

Investigational Site Number : 6160001, Lodz

45-401

RECRUITING

Investigational Site Number : 6160002, Opole

4464-513

RECRUITING

Investigational Site Number : 6200001, Matosinhos Municipality

4434-502

RECRUITING

Investigational Site Number : 6200002, Vila Nova Gaia

831 01

RECRUITING

Investigational Site Number : 7030004, Bratislava - Kramare

03659

RECRUITING

Investigational Site Number : 7030001, Martin

08025

RECRUITING

Investigational Site Number : 7240004, Barcelona

08035

RECRUITING

Investigational Site Number : 7240001, Barcelona

M6 8HD

RECRUITING

Investigational Site Number : 8260004, Salford

OX3 7LE

RECRUITING

Investigational Site Number : 8260005, Oxford

LE5 4PW

RECRUITING

Investigational Site Number : 8260001, Leicester

Sponsors

Lead Sponsor

All Listed Sponsors
lead

Sanofi

INDUSTRY

NCT06500702 - A Study to Evaluate the Efficacy and Safety of Frexalimab, Brivekimig, or Rilzabrutinib in Participants Aged 16 to 75 Years With Primary Focal Segmental Glomerulosclerosis or Minimal Change Disease | Biotech Hunter | Biotech Hunter