A Study of GFH375 in Patients With Advanced Solid Tumors With KRAS G12D Mutations

PHASE1/PHASE2RecruitingINTERVENTIONAL
Enrollment

390

Participants

Timeline

Start Date

July 9, 2024

Primary Completion Date

July 31, 2028

Study Completion Date

December 31, 2028

Conditions
KRAS G12D MutationsAdvanced Solid Tumors
Interventions
DRUG

GFH375

GFH375 will be administered at the assigned dose level, orally, until disease progression or intolerable toxicity.

Trial Locations (20)

201210

RECRUITING

Shanghai Chest Hospital, Shanhai

Unknown

NOT_YET_RECRUITING

The First Affiliated Hospital of Anhui Medical University, Hefei

RECRUITING

Cancer Hospital, Chinese Academy of Medical Sciences, Beijing

RECRUITING

Peking Union Medical College Hospital, Beijing

RECRUITING

Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou

RECRUITING

The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou

NOT_YET_RECRUITING

Guangxi Medical University Cancer Hospital, Nanning

NOT_YET_RECRUITING

Harbin Medical University Cancer Hospital, Haerbin

RECRUITING

The First Affiliated Hospital of Zhengzhou University, Zhengzhou

RECRUITING

Union Hospital Tongji Medical College Huazhong University of Science and Technology, Wuhan

RECRUITING

Hunan Cancer Hospital, Changsha

RECRUITING

Jiangsu Province Hospital, Nanjing

NOT_YET_RECRUITING

Liaoning Cancer Hospital & Institute, Shenyang

RECRUITING

The First Affiliated Hospital of China Medical University, Shenyang

RECRUITING

Shandong Cancer Hospital, Jinan

NOT_YET_RECRUITING

Sichuan Cancer Hospital, Chengdu

NOT_YET_RECRUITING

Tianjin Medical University Cancer Institute & Hospital, Tianjing

NOT_YET_RECRUITING

The First Affiliated Hospital Zhejiang University School of Medicine, Hangzhou

RECRUITING

The Second Affiliated Hospital Zhejiang University School of Medicine, Hangzhou

RECRUITING

Zhejiang Cancer Hospital, Hangzhou

All Listed Sponsors
lead

Genfleet Therapeutics (Shanghai) Inc.

INDUSTRY